IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities
Identifieur interne : 000331 ( France/Analysis ); précédent : 000330; suivant : 000332IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities
Auteurs : J. L. Martal [France] ; N. M. Chêne [France] ; L. P. Huynh [France] ; R. M. L'Haridon [France] ; P. B. Reinaud [France] ; M. W. Guillomot [France] ; M. A. Charlier [France] ; S. Y. Charpigny [France]Source :
- Biochimie [ 0300-9084 ] ; 1998.
English descriptors
- Teeft :
- Acid sequence, Acid sequences, Amino, Amino acid sequences, Amino acids, Ancestor gene, Antiluteolytic, Antiluteolytic activities, Antiluteolytic activity, Antiproliferative, Antiproliferative activities, Antiproliferative activity, Antivirai activity, Antiviral, Antiviral activities, Antiviral activity, Binding sites, Biological activities, Biologie mol6culaire elsevier, Bolfnt, Bovine, Bovine blastocysts, Bovine cells, Bovine gene, Branch point, Carboxyl, Carboxyl tail, Cell lines, Chromosome, Clone, Conceptus, Conformation, Consensus sequence, Control values, Corpus luteum, Crystal structure analysis, Cyclic, Cyclic ewes, Cytokine, Cytoplasmic domain, Cytotoxicity, Daudi cells, Different effects, Disulfide, Disulfide bond, Disulfide bridges, Diverged, Early pregnancy, Edna, Embryo, Encoding, Endometrial, Endometrial cells, Endometrium, Estrogen, Eutherian orders, Ewe, Extensive hydrogen, Extracellular domains, Fetal, Gene, Gene expression, Greater identity, Helices bind, Helix, High affinity, High concentrations, High level, Higher binding affinity, Human cells, Human clone, Human placenta, Human species, Human therapy, Human trophoblast, Hydrophobic core, Ifna, Ifnar, Ifnb, Ifnot, Ifns, Ifnt, Ifnw, Interferon, Interferon genes, Mammalian type, Martal, Maternal pregnancy recognition, Maternal recognition, Maternal uterine environment, Mdbk, Mdbk cells, Molecular mass, Mrna, Murine, Novel subtype, Other hand, Other ifns, Other type, Ovine, Ovine conceptus, Ovine ifnar, Ovine trophoblast, Ovlfnt, Oxytocin, Peptide, Pivotal role, Polymorphisme humain, Porcine, Positive darwinian selection, Pregnancy, Pregnant ewes, Progesterone, Promoter, Promoter region, Pulsatile, Receptor, Receptor binding, Receptor binding affinity, Receptor genes, Recombinant, Recombinant murine, Regulatory element, Ruminant, Second disulfide bridge, Short period, Signal transduction, Structural characteristics, Structural localization, Suborder, Suborder ruminantia, Successive rounds, Synthetic peptide, Synthetic peptides, Transcription, Transcription factor, Translation initiation site, Trophoblast, Trophoblast expression, Unpublished data, Untranslated region, Uterine, Uterine epithelium, Virus inducible.
Abstract
Abstract: IFN-tau (IFN-τ) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-α and IFN-β, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition of pregnancy in ruminants and it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity at high concentrations in vitro in cell culture and possibly in vivo. It exhibits high antiretroviral activity against HIV and exhibits immunosuppressive activity in a multiple sclerosis model and reduces embryo and fetal mortality by stimulation of IL-10 production. In this review all the biochemical and para-hormonal properties of this novel IFN-τ are described in detail: structural characteristics of proteins and genes, trophoblast expression, regulation of its expression, structure of its gene promoter, its absence in human species and in non-ruminant animals, the evolution of the IFN-τ genes, its structure-function relationships with its three-dimensional structure, structural localization of biological activities, its lack of cytotoxicity and its receptor. Surprisingly, for an IFN, IFN-τ is also a pregnancy-embryonic signal with paracrine antiluteolytic activity. In order to maintain luteal progesterone secretion, IFN-τ inhibits PGF-2α pulsatile secretion and oxytocin uterine receptivity in early pregnancy. It is believed to suppress pulsatile release of endometrial PGF-2α by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2α ratio.
Url:
DOI: 10.1016/S0300-9084(99)80029-7
Affiliations:
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sequence</term><term>Acid sequences</term><term>Amino</term><term>Amino acid sequences</term><term>Amino acids</term><term>Ancestor gene</term><term>Antiluteolytic</term><term>Antiluteolytic activities</term><term>Antiluteolytic activity</term><term>Antiproliferative</term><term>Antiproliferative activities</term><term>Antiproliferative activity</term><term>Antivirai activity</term><term>Antiviral</term><term>Antiviral activities</term><term>Antiviral activity</term><term>Binding sites</term><term>Biological activities</term><term>Biologie mol6culaire elsevier</term><term>Bolfnt</term><term>Bovine</term><term>Bovine blastocysts</term><term>Bovine cells</term><term>Bovine gene</term><term>Branch point</term><term>Carboxyl</term><term>Carboxyl tail</term><term>Cell lines</term><term>Chromosome</term><term>Clone</term><term>Conceptus</term><term>Conformation</term><term>Consensus sequence</term><term>Control values</term><term>Corpus luteum</term><term>Crystal structure analysis</term><term>Cyclic</term><term>Cyclic ewes</term><term>Cytokine</term><term>Cytoplasmic domain</term><term>Cytotoxicity</term><term>Daudi cells</term><term>Different effects</term><term>Disulfide</term><term>Disulfide bond</term><term>Disulfide bridges</term><term>Diverged</term><term>Early pregnancy</term><term>Edna</term><term>Embryo</term><term>Encoding</term><term>Endometrial</term><term>Endometrial cells</term><term>Endometrium</term><term>Estrogen</term><term>Eutherian orders</term><term>Ewe</term><term>Extensive hydrogen</term><term>Extracellular domains</term><term>Fetal</term><term>Gene</term><term>Gene expression</term><term>Greater identity</term><term>Helices bind</term><term>Helix</term><term>High affinity</term><term>High concentrations</term><term>High level</term><term>Higher binding affinity</term><term>Human cells</term><term>Human clone</term><term>Human placenta</term><term>Human species</term><term>Human therapy</term><term>Human trophoblast</term><term>Hydrophobic core</term><term>Ifna</term><term>Ifnar</term><term>Ifnb</term><term>Ifnot</term><term>Ifns</term><term>Ifnt</term><term>Ifnw</term><term>Interferon</term><term>Interferon genes</term><term>Mammalian type</term><term>Martal</term><term>Maternal pregnancy recognition</term><term>Maternal recognition</term><term>Maternal uterine environment</term><term>Mdbk</term><term>Mdbk cells</term><term>Molecular mass</term><term>Mrna</term><term>Murine</term><term>Novel subtype</term><term>Other hand</term><term>Other ifns</term><term>Other type</term><term>Ovine</term><term>Ovine conceptus</term><term>Ovine ifnar</term><term>Ovine trophoblast</term><term>Ovlfnt</term><term>Oxytocin</term><term>Peptide</term><term>Pivotal role</term><term>Polymorphisme humain</term><term>Porcine</term><term>Positive darwinian selection</term><term>Pregnancy</term><term>Pregnant ewes</term><term>Progesterone</term><term>Promoter</term><term>Promoter 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xml:lang="en">Abstract: IFN-tau (IFN-τ) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-α and IFN-β, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition of pregnancy in ruminants and it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity at high concentrations in vitro in cell culture and possibly in vivo. It exhibits high antiretroviral activity against HIV and exhibits immunosuppressive activity in a multiple sclerosis model and reduces embryo and fetal mortality by stimulation of IL-10 production. In this review all the biochemical and para-hormonal properties of this novel IFN-τ are described in detail: structural characteristics of proteins and genes, trophoblast expression, regulation of its expression, structure of its gene promoter, its absence in human species and in non-ruminant animals, the evolution of the IFN-τ genes, its structure-function relationships with its three-dimensional structure, structural localization of biological activities, its lack of cytotoxicity and its receptor. Surprisingly, for an IFN, IFN-τ is also a pregnancy-embryonic signal with paracrine antiluteolytic activity. In order to maintain luteal progesterone secretion, IFN-τ inhibits PGF-2α pulsatile secretion and oxytocin uterine receptivity in early pregnancy. It is believed to suppress pulsatile release of endometrial PGF-2α by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2α ratio.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Jouy-en-Josas</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Martal, J L" sort="Martal, J L" uniqKey="Martal J" first="J. L." last="Martal">J. L. Martal</name></region><name sortKey="Charlier, M A" sort="Charlier, M A" uniqKey="Charlier M" first="M. A." last="Charlier">M. A. Charlier</name><name sortKey="Charpigny, S Y" sort="Charpigny, S Y" uniqKey="Charpigny S" first="S. Y." last="Charpigny">S. Y. Charpigny</name><name sortKey="Chene, N M" sort="Chene, N M" uniqKey="Chene N" first="N. M." last="Chêne">N. M. Chêne</name><name sortKey="Guillomot, M W" sort="Guillomot, M W" uniqKey="Guillomot M" first="M. W." last="Guillomot">M. W. Guillomot</name><name sortKey="Huynh, L P" sort="Huynh, L P" uniqKey="Huynh L" first="L. P." last="Huynh">L. P. Huynh</name><name sortKey="L Haridon, R M" sort="L Haridon, R M" uniqKey="L Haridon R" first="R. M." last="L'Haridon">R. M. L'Haridon</name><name sortKey="Reinaud, P B" sort="Reinaud, P B" uniqKey="Reinaud P" first="P. B." last="Reinaud">P. B. Reinaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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